A team of researchers formed by Roswell Park Comprenhensive Cancer Center has carried out a new study on the vitamin D levels, on which they assure that they could play an essential role in breast cancer.
Specifically, this research work has been presented at the annual meeting of the American Society of Clinical Oncology (DISGUST), which this year 201 was held virtually. Thus, the study specifies that people with optimal vitamin D levels at the time of breast cancer diagnosis have better results.
This new research, whose first author is Song Yao, is based on the Kaiser Permanente Northern California Pathways Study, a large prospective study in breast cancer patients that has been underway since 2006, under the direction of Larry Kushi.
Dr. Yao is an eminence in the field of molecular epidemiology. In addition, he is also a professor of oncology in the Department of Cancer Prevention and Control of Roswell park.
On this research work, he highlights that “our findings from this large observational cohort of breast cancer survivors with long-term follow-up provide the strongest evidence to date for maintaining sufficient vitamin D levels in breast cancer patients, particularly black women and patients with more advanced stage disease ”.
He then goes on to explain that “these findings highlight not only the role of vitamin D in the prognosis of breast cancer, but also the contribution and need for prospective studies in cancer survivors to complement clinical trials.”
How vitamin D interacts in a breast cancer patient
To conduct this revealing research work, the researchers measured the 25-hydroxyvitamin D (25OHD) levels of a total of 3,995 women with breast cancer who were enrolled in the Pathways Study.
To carry out this analysis, the researchers used blood serum samples taken at the time of breast cancer diagnosis. Next, they examined the determinants of 25OHD levels, the intake of vitamin D supplements, the body mass index or the race. According to Dr. Yao, the genetic variants had minimal impact.
In this sense, Dr. Yao explains that “having clinically sufficient levels of vitamin D at the time of breast cancer diagnosis is associated with better outcomes.” This was one of the great conclusions of this research work.
Furthermore, he specifies that these results “are consistent with our previous analysis based on a subset of the study population, it is significant that we saw the same trends in this much larger and longer term data set. Suggesting continued benefit for patients who maintain sufficient levels through and beyond breast cancer treatment. ‘
Other variants associated with breast cancer
On the other hand, the study also observed different links between vitamin D levels and breast cancer diagnosis in relation to body index.
Specifically, in people with a lower body mass index, the link between vitamin D and the outcomes for this type of cancer appeared to be stronger. In addition, black women also presented worse values of vitamin D in the body, which could lead to a worse diagnosis of breast cancer.
Ultimately, the lead author of this study, Christine Ambrosone, notes that “our findings support the use of daily vitamin D supplements to maintain sufficient vitamin D levels after breast cancer diagnosis, particularly among black women and older adults. patients diagnosed with advanced stage disease ”.